On 13 June 1976, Lindiwe Nonceba Sisulu was detained for her involvement in political activities. The police suspected her of being in possessions of the then banned African National Congress (ANC) funds. She spent 11 months in detention. Thereafter she joined Umkhonto we Sizwe (MK) while in exile and later underwent military training, specialising in intelligence.
In 1990 she returned to South Africa just after the unbanning of the ANC and became a personal assistant to President Jacob Zuma. Sisulu, worked as an administrator in the ANC’s Department of Intelligence and Security. On 25 May 2014, Lindiwe Nonceba Sisulu became the Minister of Human Settlement of the Republic of South Africa.