Wessel Johannes "Hansie" Cronje was born in Bloemfontein on 25 September 1969 to Ewie and San-Marie Cronje. He attended Grey College in Bloemfontein, a prestigious private boy’s school. Hansie graduated as the head of his class after completing his matriculation in 1987.
An excellent all-round sportsperson, he represented the Free State (then Orange Free State) at cricket and rugby at schools level. His father Ewie had played for Orange Free State in the 1960s, and Hansie's older brother Frans had also played first-class cricket.