The superior administrative division is Vhembe District Municipality, Limpopo, South Africa. The estimate terrain elevation above seal level is 813 metres. It is situated approximately 140
km to the north-east of Polokwane, 60 km to the north-east of Makhado, 120 km to the south of Musina and 138 km to the south of the Beitbridge border to Zimbabwe. There are three formal villages situated near the Nzhelele Nature Reserve, namely the Makushu village 1.6 km to the west, Mufongodi village 3.3 km to the east and Musekwa village 2 km to the south-east of the reserve. The reserve can be accessed via the R525 off the N1 to Musina, or from the Pafuri Gate in the Kruger National Park via the R525. The Nzhelele Nature Reserve covers a total area of 2122.078 ha.