Sam P. Sesedi was born in 1895 in Kimberley and qualified as a teacher in 1916. He later obtained a B.A. degree by private study at the age of 50. After teaching for many years, he went into business as a butcher in Kimberley. An executive member of both the All African Convention and the African National Congress (ANC) in the 1940s, Sesedi rejected the boycott policy of these organisations and ran successfully for election to the Natives' Representative Council in 1949, winning the Cape rural constituency. He was at that time the president of the Location Advisory Boards Congress. He died in 1960.